All you oncologists out there should find this one interesting — an infectious cancer in Tasmanian devils that originated in a single animal’s Schwann cells and is spreading via “direct contagion” to other animals.

Cancer as parasite is an analogy I’ve been aware of, but I’ve never seen a cancer spreading between animals as a direct parasite (generally contagious spread is a result of viral hijacking causing changes in DNA that then leads to cancer).

Interesting — and potentially a disruptive way to think about cancer biology.

Scientists Report Findings on Origin of a Cancer in Tasmanian Devils – NYTimes.com.

The Tasmanian devil, the spaniel-size marsupial found on the Australian island of Tasmania, has been hurtling toward extinction in recent years, the victim of a bizarre and mysterious facial cancer that spreads like a plague.

Now Australian scientists say they have discovered how the cancer originated. The finding, being reported Friday in the journal Science, sheds light on how cancer cells can sometimes liberate themselves from the hosts where they first emerged. On a more practical level, it also opens the door to devising vaccines that could save the Tasmanian devils.

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 | Posted by Vijay Goel, M.D. | Categories: science, trials | Tagged: , |

We appear to be entering an era of uncertainty, where once again we realize that the practice of medicine is an art, not a science.

While doctors may carry scientific tomes in their heads and engineering marvels on and around their persons (although surprisingly few computers to date), the clinical practice of medicine is being rediscovered as an art, not a cookbook science. As new studies challenge the existing metrics evaluating risk through a black/ white approach dedicated to lowering intermediate clinical markers (see cholesterol for the otherwise low risk patient, glucose for Type 2 diabetics, BMI for the overweight, quantity of bloodborn “humors” to be released by lancet, etc)

Big lesson: Lower does not mean better

So, as we find out that cookbook medicine may actually be harmful in addition to being expensive, we have the same issue that is currently cracking the mortgage industry: evaluating and managing risk is hard and replacing underwriting with automation and customer service reps leads to problems when real judgment is required.

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